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Research by Dhillo, Jayasena, and Comninos at Imperial College London has established that kisspeptin signaling is dysregulated in PCOS, and that administering exogenous kisspeptin can trigger coordinated LH surges in women with the condition.[8] A phase 2 trial demonstrated that subcutaneous kisspeptin administration successfully triggered ovulation in a proportion of women with PCOS who had not responded to conventional ovulation induction, including clomiphene citrate.[9] This is a genuinely novel therapeutic signal kisspeptin addresses a mechanism that metformin, combined oral contraceptives, and clomiphene do not touch

, University of Kansas 20+ years of clinical experience Dr

Nothing, even rx meds didnt work, especially the first 3-4 months

Finally, many studies had a short follow-up duration and, therefore, we were not able to comment on the long-term effects of B12 therapy