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10.1002/alr.22065 199 UddinM.WatzH.MalmgrenA.PedersenF

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The conversion into tyrosine is tightly regulated by the enzyme phenylalanine hydroxylase (PAH), an enzyme that requires tetrahydrobiopterin (BH 4 ) as a cofactor, and molecular dioxygen as a substrate (Kaufman, 1958

Other symptoms that may accompany a mouth ulcer include: mild swelling or redness around the affected area a burning or tingling sensation in the area beforethe sore appears pain or irritation from certain foods, especiallyspicy or acidic foods bleeding from the ulcer if it becomes irritated Experts do not fully understand why aphthous ulcers occur