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Stimulation of macrophages with HGF results in differentiation of M1 macrophages to M2 subtypes (64), underscoring the functional relevance of HGF/Met axis in the antitumor immune response

As additional mechanisms for regulating GPCR signaling are uncovered, new strategies for targeting these ubiquitous receptors hold tremendous promise for the field of cardiovascular medicine

Pellets were resuspended in DMEM/F-12 medium (Life Technologies, Carlsbad, CA, USA) supplemented with 20% foetal bovine serum (FBS, Pan Biotech, Aidenbach, Germany) and penicillin/streptomycin (Life Technologies) and plated on 10 cm cell-culture dishes

XBP-1S and P-IRE1 antibodies were in-house reagents