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Additional studies on cytokines and chemokines have shown an augmentation of IL-2 (which stimulates the growth of helper, cytotoxic and regulatory T cells), IL-17 (which is associated with inflammation and autoimmunity), interferon (IFN)- (which is critical for innate and adaptive immunity against viral infections), CCL3 and CCL5 in the early phase of LC [25,178,220,223,224]

Because skeletal muscle contains most of the bodys phosphocreatine and creatine reserve, urinary creatinine excretion varies according to muscle mass, being on average lower in women than in men [10]

For pharmacological therapies, the NPG members included antidepressants, antiepileptics and opioids and also included a chapter on cannabinoids and dietary supplements