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Furthermore, the more recent observational data suggesting that the combination of high folate and low vitamin B-12 is associated with the worsening of both clinical outcomes and elevations in functional biomarkers of vitamin B-12 (23, 40, 41) imply that depletion of holoTC is attained even without stimulating hematopoiesis

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Some studies have reported that increased expression of ATGL and DAGT prolonged the lifespan of Drosophila [54] and Caenorhabditis elegans [55, 56]