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However, the effects of this compound are clearly pleiotropic: in some cell lines sorafenib triggers apoptosis [37], and even in cell lines where ferroptosis is observed at low doses of sorafenib, apoptosis or some other form of cell death is observed at higher doses [28]

WCA (0.4 mg/mL) downregulated the expression of MMP7, MMP9, zinc finger E-box binding homeobox 1 (ZEB1), and -catenin to anti-CRC migratory and invasive in HCT116 cells (Tao et al., 2019)

This mechanism enhanced VE-Cadherin expression and localization, protecting the endothelial barrier and suggesting potential therapeutic applications for alleviating IBD