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Predicting the efficacy of c-MET inhibitor in combination with ICI therapy The malfunction of MET affects the expression of PD-L1 in tumors through complex and varied pathways

1 At high concentrations K m ) m max Clinical Implications of Michaelis-Menten Kinetics Drugs that have a therapeutic range that falls on the steep, transitional part of the Michaelis-Menten curve are said to have a narrow therapeutic index and pose significant clinical challenges

The cells were then permeabilized and stained with PerCP/Cyanine5.5 anti-CD206 antibody at 4 for 30 min before being washed again