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We quantified the number of filopodia in cells transfected with MYO6+ WT , MYO6+ S267A or MYO6+ S267E and found that the number of filopodia was significantly increased in cells expressing the MYO6+ S267E construct with an average of 120.7 18.6 (mean SD) filopodia per cell compared with MYO6+ WT with 65.45 26.83 and MYO6+ S267A with 51.5 9.37 (Fig

Subsequently, the expression of Drp1 and Fis1 was up-regulated, while down-regulated expression of Opa1 and Mfn1 was observed, which indicated the effect of silibinin to enhance mitochondrial fission and to weaken mitochondrial fusion

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