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Intriguingly, a recent study shed new light on the role of Apolipoprotein E4 (APOE4), a major genetic risk factor associated with AD, in AD-linked cholesterol dysregulation and demyelination [78]

Redox regulation of NK-cell activation and function Increased ROS production enables NK-cell-mediated cytolysis by promoting the release of perforin and granzyme B [381] and NK-cell division and proliferation after pathogen invasion [382]