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SCHEME 1 2 The wound healing process Wound healing is a complex process that involves interactions between different cell types, cytokines, antioxidants, and ECMs (Scheme 2) ( SCHEME 2 3 Properties of gelatin Gelatin is obtained through the acid, alkali, or hot water hydrolysis of natural collagen, and its main structure is similar to collagen ( ECM serves as a dynamic environment for cell survival and is crucial in cell growth, mechanical support, and nutrient supply ( 4 Gelatin-based biomaterials promote wound healing 4.1 Hemostasis Bleeding is a direct manifestation of skin damage, and uncontrolled bleeding is the leading cause of trauma death ( In vivo experiments in a mouse hepatocellular carcinoma hemorrhage model, the gel binder had less bleeding and shorter hemostasis than the control group

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