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For example, ROS drive hypoxia-inducible factor 1 (HIF1) mediated GLUT1 expression, hexokinase activity, and resultant glycolysis in response to low oxygen tension as part of the angiogenic response (27) The co-localization of neutrophil phosphofructokinase 2 with NOX2 leads to its activation, resulting in NADP+ production as its byproduct, facilitating an enhanced glycolytic rate

The findings indicate that curcumin has the capacity to regulate the function and expression of these transportation proteins, hence playing a key role in counteracting MDR of cancer cells

Table 8 The effects of [MPs] additives on the mammalian pituitary gland

Nat Commun 8 , 16087 (2017)