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One of the key findings of our study was the significant decrease in serum MDAlevels in the IF group

Further mechanistic investigations have implicated GHK-Cu in the activation of the Nrf2/ARE antioxidant response pathway in cultured cells, where it appears to reduce reactive oxygen species (ROS) burden independently of direct radical scavengingsuggesting an indirect, gene-regulatory mode of action rather than purely stoichiometric antioxidant chemistry

doi: 10.1128/jcm.28.11.2398-2402.1990 211 HildesheimALevinePH

While the genes upregulated more by decursinol angelate primarily encode growth factors, the genes upregulated more by decursin primarily encode extracellular matrix (ECM) remodelling proteins and inflammatory cytokines