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[DOI] [PubMed] [Google Scholar] 21.Zhu Z, Cui L, Yang J, et al

If increased homocysteine or methylmalonic acid levels and a normalization of these metabolites in response to replacement therapy are used as diagnostic criteria for vitamin B 12 deficiency, approximately 50 percent of these patients have serum vitamin B 12 levels above 200 pg per mL

However, the kit was discontinued in 2005 and while it was advised that WADA pursue the development of an in-house assay to prevent such occurrences, the subsequent GH-2004 team chose to implement alternative commercial assays such as the DSL-5600 and Immunotech A15729 immunoradiometric assays, apply conversion factors to align results and make use of the reference range data that had been built using the prior assay [102]