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Description
Data were expressed as permeability ( P app ) calculated using the following formula: Efflux Ratio (R e ) was calculated using the formula: 2.4

Decrease dose consideration: Persistent side effects including headaches, fatigue, or injection site reactions, excessive response (extremely rapid weight loss suggesting dose may be higher than needed), cost concerns when lower doses might achieve similar results
When in doubt, use compounds sequentially rather than simultaneously, rotating through different mechanisms during consecutive cycles
Each vial is sealed and shipped with a tamper-evident seal
