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10.1111/mmi.13937 Mol
The human F box protein -Trcp associates with the Cul1/Skp1 complex and regulates the stability of -catenin

Role and function of peroxisomes in neuroinflammation

The deficiency in activity may come about via a total absence of enzyme protein caused by a mutation of the nuclear gene that produces no mRNA or produces mRNA leading to a defective or unstable enzyme, via a defective post-translational modification of the lysosomal enzyme, or via the absence of a specific activator protein required by some enzymes for the initiation of activity
