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This literature supports the broader premise that microbiome disruption could reduce the stability of neuroendocrine stress regulation, thereby sustaining arousal signals that are adverse for restorative sleep (

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Supervised learning is the most widely used ML paradigm in drug discovery

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& Pai, R

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IL-1beta stimulates IL-6 production in cultured skeletal muscle cells through activation of MAP kinase signaling pathway and NF-kappa B

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