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Depending on the involved loads and direction of force, it can range from a subclinical strain of some annular fibers (whiplash injury) that would be referred to the disc injury type A1 over a traumatic disc herniation (injury type B) to a complete dislocation with separation of the segment, disruption of the annular fibers, longitudinal ligaments, joint capsule and posterior structures (disco-ligamentous complex, DLC) that would be injury type C

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It was found that the expression of GCH1 triggers the production of potent antioxidants BH4/BH2, which can block lipid peroxidation and ferroptosis, whether supplemented exogenously or produced endogenously

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