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doi: 10.1126/science.1074069

Ghrelin receptor is characterized by its high basal activity, with approximately 50% of its maximal capacity in the absence of a ligand 12,13

In addition, the results of an in vitro permeation study on rat skin revealed that drug accumulation within the skin layers was approximately 3 times higher, while the drug flux into the receptor phase of Franz cells was about 6.5 times lower in hydroquinone-loaded SLNs in comparison to the hydroquinone gels which confirmed the reduced systemic absorption and further reduced adverse drug reactions through the encapsulation in SLNs (Wu et al., 2017)

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