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RNA studies on GHK-Cu have shown that GHK-Cu remodells the destructive proteolysis by triggering the upregulation of ECM synthetic genes (COL1A1, COL3A1, elastin, decorin) and glycosaminoglycans biosynthesis genes, and modulation of matrix metalloproteinases

In some embodiments, the auris-acceptable penetration enhancer is a surfactant comprising an alkyl-glycoside wherein the alkyl-glycoside has a critical micelle concentration (CMC) of less than about 1mM in pure water or in aqueous solutions

[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Yan-Do R., MacDonald P.E

A compound may lose most of its active effects relatively quickly while traces remain detectable for a longer period