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Acknowledgements All the authors are grateful to Arnould Savour, coordinator of the PHC Maghreb project, Pierre Carol from Sorbonne University (Paris, France) and Pr Ouzna Abrous-Belbachir, leader of Algerian team of the project

Mice were euthanized in a CO 2 chamber when reaching humane end point (1500 mm 3 )

10.1016/j.cell.2015.11.031

The authors intuited that 4-HNE could contribute to the oxidative damage of skin proteins [58]
