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It downregulates inflammatory mediators such as IL-6, indirectly modulating hepc activity and restoring iron homeostasis (87, 88)
phosphoinositide 3-kinase (PI3K)-Akt, extracellular signal-regulated kinase (ERK) and p38 have all been reported to contribute to cellular damage (101,102)
Shah & Beuhler noted that simplified, single-bag HD-NAC decreased the risk of hepatotoxicity in high-risk ingestions
