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Revista Espaola de Enfermedades Digestivas, 103(6), 332

4 Methadone exposure may be associated with motor delays during the first year of life

Materials and Methods The study was a randomized, double-blind, placebo-controlled trial (registered at clinicaltrials.gov as NCT00641862)

These delayed reactions are usually localized to the injection site and include symptoms such as itching, swelling, or bruising, typically mild and manageable with home care