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Animal studies show that long-term carnitine supplementation promotes mitochondrial biogenesis in skeletal muscle, heart, and brain tissue of aging subjects through upregulation of PPAR-coactivator-1 (PGC-1), a master regulator of mitochondrial biosynthesis and function

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So, its too soon to say how safe and effective pine bark extracts are for treating specific illnesses ( As more research is conducted, well gain a better understanding of the best ways to use pine bark extract

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Gomez, and M

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Acknowledgements This work was funded by grants from the Basic Science Research Program grants through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (RS-2023-00245904 awarded to L.A) and grant for Medical Research Center funded by the Ministry of Science and ICT (2021R1A5A2031612 awarded to J-K.R.)

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