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Metformin also has indirect anti-tumour effects by reducing insulin and insulin-like growth factor 1 levels, which promote tumour growth and proliferation
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Int J Mol Sci 24(10):8465
[33] In a proof-of-concept study, zoledronic acid, a bisphosphonate commonly used in treatment of osteosarcoma and cancer-induced osteoporosis, was found to be senolytic and senomorphic under in vivo conditions
