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White matter hyperintensity burden is higher in patients with PD dementia and MCI compared to patients with intact cognition 157

This increase can be caused by Ca 2+ entry through ion channels, such as L-type Ca 2+ channels an P2X 2 ATP receptor subunit, and lead to further release of Ca 2+ from intracellular stores such as the ER and mitochondria (Orrenius et al., 2003)

In the proposed mechanism, xylitol induces Bip and CHAC1, resulting in decreased cellular GSH levels, ER stress, and ultimately apoptotic cell death

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