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Little change in symptoms day 10 after 2nd shot except for added low-grade fever in afternoon/evening

Studies in this systematic review support B12 supplementation for the treatment or prevention of metformin-induced deficiency and neuropathy, demonstrating increased levels of B12 and decreased serum homocysteine with supplementation

Acknowledgements The study was funded by InBrain Pharma, France, a spin-off of the research academic team UMR-S 1172 (University of Lille, INSERM, University Hospital of Lille), which delegated the promotion of the study to the University Hospital of Lille, France

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