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Another compound, HPP971, elevated reduced GSH levels and protected human astrocytes from H 2 O 2 -induced cell death in vitro and induced HO1 expression in a murine EAE model of MS, attenuating loss of motor functions [304]

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[13] Chloramphenicol has been shown to blunt reticulocyte response to cyanocobalamin, while ethanol, colchicine, and nitrous oxide interfere with cobalamin metabolism or utilization, each warranting clinician awareness when evaluating suboptimal treatment outcomes