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Microneedle-based intradermal delivery enables rapid lymphatic uptake and distribution of protein drugs
In addition, the anti-tumor efficacy was also confirmed by H&E staining, as shown in Supplementary Fig
In the field of histone modification, panobinostat, an HDAC inhibitor that belongs to the cinnamic hydroxamic acid class of compounds that inhibits HDAC1, 36 at nanomolar concentrations [133, 134], has exhibited cytotoxic effects by inducing cell cycle arrest and apoptosis in ATC cell lines both in vitro and in vivo [51], but its clinical efficacy remains limited
Clioquinol decreases amyloid- burden and reduces working memory impairment in a transgenic mouse model of alzheimers disease
