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How to model rheumatoid arthritis in animals: From rodents to non-human primates

Polymorphisms in detoxification genes such as glutathione S-transferases decreased the ability to detoxify cyclophosphamide metabolites due to lower enzyme activity, which leads to increased amounts of toxic metabolites and the development of III-IV acute GVHD

Thus, a human albumin variant resistant to enzymatic cleavage by CPA could not be obtained through L585 engineering without compromising FcRn binding

Corra-Ferreira ML, Verdan MH, dos Reis Lvero FA, Galuppo LF, Telles JE et al (2017) Inulin-type fructan and infusion of Artemisia vulgaris protect the liver against carbon tetrachloride-induced liver injury