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E2 activation of phosphatidylinositol-3 kinase and suppression of the tumor suppressor and phosphatidylinositol-3 kinase inhibitory protein, PTEN, is also well-established (229233) in breast cancer cell lines, endothelial cells, and cortical neurons, suggesting a potential effect of E2 in modulating insulin-stimulated effects on these critical signaling molecules

For analysis of the remyelination courses, mice were fed with the same dose of CPZ for 5 weeks and then returned to normal chow without CPZ for recovery from demyelination for 1-4 weeks before sampling