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Tryptophan (Trp) metabolism, and consequently Trp-derived metabolite pathways such as the kynurenine and serotonin pathways, have long been known to be central to the pathophysiology of MDDlower blood concentrations of Trp have been described in several studies of MDD patients, and alterations in tryptophan and kynurenine levels have also been associated with symptomatology and treatment [24, 74]

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Always consult with a healthcare provider before beginning any supplementation regimen

Adverse reactions related to supplementation were reported in four studies [13, 1719], whereas the remaining three [1416] did not specify whether they gathered such information