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Notably, the clinical evidence does not support a desensitization requirement: the Biolcati et al

The first effects appear progressively : Weeks 1-2 : better energy during training, reduced post-workout fatigue sensation Weeks 2-4 : improved recovery, first measurements on waist circumference for weight loss profiles Weeks 4-8 : measurable improvement in endurance, more visible fat loss Weeks 8-12 : full effects in terms of body composition and performance L-carnitine saturation of muscle levels takes several weeks because intramuscular concentration increases slowly

Clinical trials in patients with metabolic syndrome reveal that L-Carnitine supplementation of 2 g/day for extended periods (25-50 weeks) significantly reduces fasting blood glucose, HbA1c, homeostatic model assessment-insulin resistance (HOMA-IR), inflammatory markers including C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-), and triglyceride levels

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