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Effects of L-carnitine supplementation for women with polycystic ovary syndrome: a systematic review and meta-analysis

[DOI] [PubMed] [Google Scholar] 133.Ribas G.S., Manfredini V., de Mari J.F., Wayhs C.Y., Vanzin C.S., Biancini G.B., Sitta A., Deon M., Wajner M., Vargas C.R

Trimethyl-lysine dioxygenase (TMLD) is the only enzyme involved in L-carnitine synthesis that is localized in the mitochondrial matrix

However, the relatively modest increase in ATP production (~22%) compared to the doubling of proton leak suggests that part of the respiratory activity may be uncoupled from ATP synthesis at the end of the study