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Since each drug of abuse has a different mechanism of BBB disruption, understanding the effect of polysubstance abuse on BBB could allow the evaluation of novel therapeutic agents and systemic prediction of clinical efficacy

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We summarize the consequences of this seemingly simple idea in the table below: Inflection points If we are trying to understand the shape of the graph of a function, knowing where it is concave up and concave down helps us to get a more accurate picture

3.2 Aging Several studies have shown that aging can have profound effects on the GI tract