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VEGF, in addition to acting as a mitogenic signal for vascular endothelial cells, protects tumor vasculature from apoptosis by inducing anti-apoptotic factors, mediates the activation of extracellular matrix degrading enzymes, and promotes tumor-immune evasion by recruiting immunosuppressive cells such as Tregs, TAMs, and MDSCs

Compared with those in nonobese patients, the serum levels of the antioxidant substances MDA, SOD, GSH, and GPX were significantly greater in the obese PCOS group (160)