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doi: 10.1038/nature11540 74 YeJMancusoATongXWardPSFanJRabinowitzJDet al

This regulatory pathway appears to be conserved in humans and nonhuman primates, since circulating FGF19 levels inversely correlate with markers of hepatic bile acid biosynthesis, administration of inhibitory anti-FGFR4 antibodies stimulated bile acid synthesis in nonhuman primates, and administration of recombinant FGF19 to human subjects strongly repressed bile acid synthesis

Cortisol has been shown to modulate anti-inflammatory responses, and chronic stress can lead to a state of glucocorticoid resistance, in which the normal anti-inflammatory effects of cortisol are diminished [316,317,318]

This is demonstrated by higher GH secretion and physiological responses seen in older adults when compared with AGHD patients of similar age (25)