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Subsequent chemical reactions, such as rearrangements and cross-linking processes, result in the loss of normal function for these biological macromolecules

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Drug Metab Dispos 37:17791784 James L, Chiew A, Abdel-Rahman S, Letzig L, Graudins A, Day P, Roberts D (2013) Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations