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2023;42 doi: 10.1016/j.celrep.2023.112666

For instance, it was shown that sulfhydration of Cys38 in p65, which stimulates its transcriptional activity, predominated early after an H 2 S-forming TNF- treatment but that it declined with time being succeeded by a reciprocal enhancement of Cys38 nitrosylation which inhibited it (Sen et al., 2012)

In a worst case-scenario, cells are incapable to degrade carcinogens or stress-induced toxic intermediates, thus increasing their susceptibility to undergo further steps toward cancer progression or event other diseases (Deep et al., 2012)

In this review, we will discuss the possible role of the CYP pathways in alcohol-mediated effects on HIV-1 pathogenesis and HAART medications as follows: i) the effects of alcohol on HIV-1 pathogenesis and neuroAIDS, ii) the role of the CYP pathway in alcohol-mediated oxidative stress and its implications in HIV-1 pathogenesis, iii) the role of the CYP system in alcoholHAART interactions and its implications in HIV-1 pathogenesis and HAART treatment, iv) conclusions, and v) expert opinion on this subject
