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STERILE INFLAMMATION AND APAP HEPATOTOXICITY The extensive cell necrosis after an APAP overdose leads to release of damage-associated molecular patterns (DAMPs) including mitochondrial DNA, nuclear DNA fragments, high-mobility group box 1 (HMGB1) protein, and many others108110 (Fig

10.1111/apt.12453 80 MalvitteL.MontangeT.VejuxA.JoffreC.BronA.Creuzot-GarcherC.et al (2008)

The greatest risk of death during this period (with common causes being cerebral edema, septic shock, or less commonly hemorrhage)

Linagliptin ameliorates acetic acid-induced colitis via modulating AMPK/SIRT1/PGC-1 and JAK2/STAT3 signaling pathway in rats
