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Excess tumor-derived lactate leads to lactic acid accumulation, which impairs CD8 + T cell effector functions through intracellular acidification and inhibition of glycolytic enzymes such as GAPDH

Mitochondrial glutathione uptake: characterization in isolated brain mitochondria and astrocytes in culture

We acknowledge support from the Biomedicum Imaging Core Facility at Karolinska Institutet, supported by the Knut and Alice Wallenberg Foundation, the Eukaryotic Single Cell Genomics Facility at the Science for Life Laboratory, Sweden, for the scRNA-seq experiments

With IV therapy, nutrients enter circulation immediately, allowing higher and more reliable serum levels which is why IV routes are used when rapid or complete delivery is required