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At the cellular level, under hypoxic conditions, the hypoxiainducible factor (HIF)prolyl hydroxylase family of enzymes (PHD13) lose their ability to hydroxylate HIF because they rely on O 2 for their enzymatic activity [139]

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Down-regulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease