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Activated UPR can restore ER homeostasis via integrated intracellular signaling (Hetz, 2012)
It directly neutralizes a wide range of oxidants, including hydroperoxides, superoxide, nitric oxide, carbon radicals, peroxynitrites, and lipid peroxides that damage cell membranes, DNA, energy production, etc
appetite suppressants and lipase inhibitors), 2) increasing energy expenditure, 3) modulating fat storage or adipocyte differentiation, or 4) mimicking caloric restriction [8,19] (Fig
