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NADPH is used to reduce the GSSG to glutathione, which is catalyzed through glutathione reductase (GR), a flavoprotein enzyme.[119] NADPH is resupplied by a reduction of NADP + via pentose-phosphate pathway [Figure 1].[118] In cases of rapid production of GSSG, or impaired GR activities, GSSG accumulation occurs, that is either transported from the cells or reacts with protein sulfhydryls (SHs), via a mixed disulfide reaction, potentially resulting in impaired protein function, and net loss of intracellular glutathione.[25] Intracellular compartmentalization of glutathione includes separate redox pools that are distinct from the cytoplasmic pools in terms of GSH/GSSG ratio, their redox potential, and their control of cellular activities

If there are just a couple of sticks holding up the bridge, it will be pretty flimsy

Md S, Abdullah S, Alhakamy NA, Shaik RA, Eldakhakhny BM, Omar UM, et al

PinheiroRTTrettimJPde MatosMBPinheiroKATda SilvaRAMartinsCRet alBrief cognitive behavioral therapy in pregnant women at risk of postpartum depression: pre-post therapy study in a city in southern Brazil