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Ca 2+ ion influx is the most important ion influx, playing a significant role as a secondary messenger in diverse cellular processes and various physiological changes (Trewavas and Malho, 1998)
Interestingly, Nrf2 is emerging as an important regulator of cellular resistance to oxidants and OS (205)
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However, treatment with the copper chelator BCS resulted in an increase in the correlation between calcium transients, which reflect synchronized action potentials produced by neurons in the circuit (Mao et al., 2001)
