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Intranasal administration may be an excellent approach for certain therapeutic effects

da Silva Lemos I, Wessler LB, Duarte MB et al (2022) Exposure to leucine alters glutamate levels and leads to memory and social impairment in zebrafish

Thats what happened with the Johnson & Johnson Covid-19 vaccine: Surveillance identified a rare risk of a severe blood clotting syndrome, particularly among some women

The inclusion of multiple flu antigens also achieves broad protection against the dominant circulating strains of influenza and enhances the overall efficacy of seasonal vaccines 41
