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Intranasal administration may be an excellent approach for certain therapeutic effects

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da Silva Lemos I, Wessler LB, Duarte MB et al (2022) Exposure to leucine alters glutamate levels and leads to memory and social impairment in zebrafish

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Thats what happened with the Johnson & Johnson Covid-19 vaccine: Surveillance identified a rare risk of a severe blood clotting syndrome, particularly among some women

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The inclusion of multiple flu antigens also achieves broad protection against the dominant circulating strains of influenza and enhances the overall efficacy of seasonal vaccines 41

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