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A Japanese clinical study (120) showed that in a phase I trial of sunitinib combined with s-1 and cisplatin in patients with GC, the MTD of sunitinib combined with cisplatin/S-1 was 25 mg/day

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These modifications collectively address the major limitations of natural amylin - its tendency to aggregate into toxic fibrils, rapid degradation, and poor pharmacokinetic properties - while preserving and enhancing its beneficial metabolic effects