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10.1021/jm900651p 77 LukaszukA.DemaegdtH.SzemenyeiE.TthG.TymeckaD.MisickaA.et al (2008)

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a subject administered a combination of a compound of formula (I) and at least one additional therapeutic agent can receive compound of formula (I) and at least one additional therapeutic agent at the same time (i.e., simultaneously) or at different times (i.e., sequentially, in either order, on the same day or on different days), so long as the effect of the combination of both agents is achieved in the subject

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