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The normalized datasets of ESI and ESI + modes were combined and input into SIMCA 13.0 software (MKS Umetrics, Malm, Sweden) to conduct various multivariate data analyses, namely, principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and orthogonal partial least squares discriminant analysis (OPLS-DA)

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Cysteine is an essential precursor for the synthesis of reduced glutathione, which combines with intracellular glycine and glutamate to synthesize the endogenous antioxidant GSH [17, 18]

Definitions Gout Gout is defined as a disorder resulting from tissue deposition of MSU crystals (in joints, bursae, bone and certain other soft tissues, such as ligaments, tendons, and, occasionally, skin) and/or crystallization of uric acid within the renal collecting system (tubules and renal pelvis) that typically occurs in acid urine ( Table 1 - 1 )