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Experimental evidence has demonstrated that folic acid can epigenetically silence the IRF5 gene, a key driver of TNF- synthesis and suppress type I and III interferon pathways, both commonly overexpressed in SLE (168)

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We previously demonstrated that growth attenuation of rv1127c in propionate is rescued by the addition of either vitamin B 12 or acetate (Basu et al, 2018), data that phenocopies Mtb mutants lacking MCC enzymes (Lee et al, 2013), thus supporting an unexpected role for Rv1127c in the MCC (Borah et al, 2021)

There were many kinds of carotenoids, among which red lycopene and yellow -carotene are dominant in tomato fruit ( SlBEL11 gene resulted in a decrease in upstream carotenoids and an increase in downstream carotenoids (Figure 1E)