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The combination produces 15-25% body weight loss - significantly superior to semaglutide's 10-15% alone - by targeting both GLP-1 and amylin receptors simultaneously

Individual patient care should always be guided by a qualified healthcare professional

Additionally, questions modified for the 2021 SDR to understand the impact of the COVID-19 pandemic on SDR measures were restored to their pre-pandemic form used in the 2019 SDR cycle, eliminating references or response options related to the pandemic

This effect on heart rate is an important safety issue that needs special attention in future trials since obese individuals are at increased cardiovascular risk